Monthly Archives: February 2015

PDE5 Inhibitors Available in the Market for Erectile Dysfunction

PDE5 inhibitors are known to be the best choice for men who are in otherwise good health but have difficulties obtaining and retaining an erection.  It is generally safe to use for most men of any age.  However, before taking PDE5 inhibitors for the treatment of erectile dysfunction, there are those who are actually not suitable for this type of drug.  Men who take nitrate medicines for angina or alpha blocker meds for benign prostatic hypertrophy and hypertension are not recommended to take PDE5 inhibitors.  Also, PDE5 inhibitors are known to be less effective in men who have been treated for prostate cancer and patients who have a medical history of diabetes in the past.

Patients with the following medical conditions are not advised not to take PDE5 inhibitors without the knowledge of their physicians:

  • Severe heart problems such as angina, arrhythmia, heart failure and heart attack episodes.
  • Hypertension (high blood pressure)
  • Hypotension (low blood pressure)
  • Recent incidence of stroke
  • Diabetes that is uncontrolled
  • Retinitis pigmentosa. This is a genetic disease in which the affected patient’s body does not produce phosphodiesterase-5 enzyme, thus, they do not respond to PDE5 inhibitors.

PDE5 Inhibitors available in the Market Today

There are currently four oral PDE5 inhibitors that are FDA approved for the treatment of erectile dysfunction or male impotence.

  • V-a (sildenafil citrate)
  • Levitra (vardenafil)
  • Cialis (tadalafil)
  • Stendra (avanafil)

All of these PDE5 inhibitors work well for patients who are suffering from erectile dysfunction issues.  PDE5 inhibitors, also called phosphodiesterase type 5 inhibitor, work by blocking the enzyme called PDE5.  PDE5 inhibitors help in relaxing the smooth muscles of the penis, thereby increasing the flow of blood to the penile shaft.  PDE5 inhibitors are typically the first choice of drugs used for the treatment of erectile dysfunction in men. Continue reading “PDE5 Inhibitors Available in the Market for Erectile Dysfunction” »